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August 2007

 

The Electronic Sarcoma Update Newsletter, Vol. 4, No. 4

Each of the words or phrases that are underlined and in a bold blue type in ESUN are hyperlinks to websites, documents or articles. Each title in the table of contents, In This Issue, is a link to the specific article. All the external hyperlinks appearing in ESUN were valid when the issue of ESUN was published. If you find any broken links, please send us a note about them. The document hyperlinks typically open PDF documents, so you should have the Adobe Acrobat Reader installed on your system in order to read them.

 

In This Issue

Feature Articles

A resource that could be of immense value to the entire sarcoma community

Editorial by Bruce Shriver

CTOS OP Ed: The Margin Matters: Someone's life depends on it

Dr. Lor Randall discusses the surgical margin.

Targeted Therapies for Sarcomas: the next generation of treatments

Dr. David Loeb reviews molecular, ligand, passive and physiological targeted therapy.

3,392 People Worldwide Demonstrate that "Sarcoma Knows No Borders"

An update on the 2007 Team Sarcoma Initiative.

The Genetic Information Nondiscrimination Act (GINA)

Orkideh Malkoc urges readers to support passage of this act.

Cancer Treatment Related Changes in Cognitive Function (a.k.a. "Chemo Brain")

Denise Reinke discusses the phenomena known as "chemo brain".

First International Chordoma Research Workshop: summary and outcomes

A workshop focused on bringing new basic-science researchers into the emerging chordoma research community.

A Partial Index to Articles that have Appeared in ESUN

We give an updated partial index to ESUN articles.

Regular Columns

Clinical Trial News 

Tom Swartz describes various clinical trials
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Currently Accepting Eligible Patients (not previously published in ESUN)

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Not Yet Recruiting Patients (not previously published in ESUN)

Odds & Ends

Pointers to resources and abstracts of interesting articles. In this issue's column:
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Specialist Centers Should Deal With All Soft Tissue Sarcomas

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CTRC Enrolls First Patients In Phase II Study; Living Virus Destroys Cancer Cells In Sarcoma Patients

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Child Cancer Patients Find Hope For Future Fertility

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Depression In Terminal Illness: The Need For Primary Care-Specific Research

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Knowledge of and Barriers to Pain Management in Caregivers of Cancer Patients Receiving Homecare

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Golfers Against Cancer Event Benefits Osteosarcoma Research

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Sensitivity To Diverse Range Of Chemotherapeutic Drugs Linked To Common Pathway

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Guidelines for Identification of, Advocacy for, and Intervention in Neurocognitive Problems in Survivors of Childhood Cancer

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Evaluation of Cognitive Function Associated With Chemotherapy: A Review of Published Studies and Recommendations for Future Research

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Early Results Find Activity In Drug That Turns on Tumor "Death" Receptors

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Positive ZIO-201 Interim Phase II Sarcoma Data Presented at European Society for Medical Oncology

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Ariad Gets $75 Million Up Front In Merck Deal On mTOR Inhibitor

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Spectrum Pharmaceuticals Completes New Drug Application Filing for ISO-Vorin(TM)

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At Press Time

Research Corner 

Abstracts of recent sarcoma-related research articles. In this issue:
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Heat Therapy Makes High-Risk Soft Tissue Sarcomas More Treatable

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Randomized Phase II Study of Gemcitabine and Docetaxel Compared With Gemcitabine Alone in Patients With Metastatic Soft Tissue Sarcomas: Results of Sarcoma Alliance for Research Through Collaboration Study 002

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Phase III Trial of Two Investigational Schedules of Ifosfamide Compared With Standard-Dose Doxorubicin in Advanced or Metastatic Soft Tissue Sarcoma: A European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study

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Docetaxel: A therapeutic option in the treatment of cutaneous angiosarcoma - Report of 9 Patients

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Tumor Angiogenesis: Cause or Consequence of Cancer?

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Multifaceted Dysregulation of the Epidermal Growth Factor Receptor Pathway in Clear Cell Sarcoma of the Kidney

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Efficacy of Trabectedin (ecteinascidin-743) in Advanced Pretreated Myxoid Liposarcomas: A Retrospective Study

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Delays in Cancer Diagnosis in Underinsured Young Adults and Older Adolescents

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Analysis of Genes Critical for Growth Regulation Identifies Insulin-like Growth Factor 2 Receptor Variations with Possible Functional Significance as Risk Factors for Osteosarcoma

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Gene Expression Profiling of Liposarcoma Identifies Distinct Biological Types/Subtypes and Potential Therapeutic Targets in Well-Differentiated and Dedifferentiated Liposarcoma

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EWS/FLI1 Regulates Tumor Angiogenesis in Ewing's Sarcoma via Suppression of Thrombospondins

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Trabectedin (ET-743): evaluation of its use in advanced soft-tissue sarcoma

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At Press Time

Stories of Courage and Hope 

Tom Swartz abstracts several inspiring stories we have recently encountered about patients or caregivers that tell of the strength that some are blessed with in dealing with sarcoma. In this issue's column:
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Dreams Do Come True

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My Face Nearly Killed Me

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Surviving To Race

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Family, Friends Help Keep Recovery On Track

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Michigan Grad Remains Optimistic As He Fights Cancer

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Miles Levin receives SFA's Leadership in Courage Award

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Indie Musician's Fight Ewing's Sarcoma

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Fall Fashion Show Makes Fighting Cancer Chic

Our Initiatives

Brief descriptions of some of the Liddy Shriver Sarcoma Initiative projects are presented. In this issue:

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2008 Team Sarcoma Initiative

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The "Sarcoma Knows No Borders" Bracelet 

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Music CD, The Circle, Benefits Sarcoma Research

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Guest Book

General Information

Disclaimer

Medical Editorial Board and Editorial Staff

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Topics and Feedback

Please send us your recommendations for topics that you would like to see covered in ESUN as well as any other comments or feedback that can be useful to us.  We also welcome contributions of essays and articles that are relevant to ESUN and its intended audience

 

V4N4 ESUN Copyright © 2007 Liddy Shriver Sarcoma Initiative.

 

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