Topotecan + Cyclophoshamide

Basic Information for Topotecan

• Topotecan is also called topotecan hydrochloride, NSC-609699, and Hycamtin

• It inhibits the action of topoisomerase I, an enzyme that produces reversible single-strand breaks in DNA during DNA replication.

• Given via IV

• Approved by FDA for ovarian and lung cancers

Basic Information for Cyclophoshamide

• Cyclophoshamide is also called Cyclo, CPA, CPM, CTX, CYC, CYT, Cytoxan, Procyton, and Neosar

• Given IV or orally

• FDA-approved for many cancers; available for decades

Related Papers

• 2000 abstract describing using cyclophosphamide and topotecan for resistant solid tumors; discusses the dosage and side effects.